KINEX® PLUS Bioactive

KINEX^® PLUS Bioactive’s components are designed to recruit and signal osteoblasts, promote early vascular development and bind proteins necessary for bone regeneration. KINEX^® PLUS utilizes The Power of Bioactive Glass™ to help promote bone formation and healing in the posterolateral spine, pelvis, and extremities.

• Cell Recruitment and Signaling
  The regeneration of damaged bone tissue involves the migration and proliferation of osteoblasts to the site. Bioglass® recruits these cells and stimulates the production of growth factors that amplify the cellular activity responsible for bone formation. _{(1, 2, 3)}
• Angiogenic Potential
  Hyaluronic acid has been shown to help promote early vascularization and attracts osteogenic precursor cells, which may lead to earlier bone formation. _{(4, 5)}
• Protein and Cell Binding
  Collagen provides a resorbable osteoconductive scaffold that binds proteins and cells. _{(6, 7)}

KINEX^® PLUS Bioactive provides exceptional handling characteristics and is available as Putty and Gel.

• KINEX^® PLUS Putty: Moldable putty that is cohesive and easily packs into in the posterolateral spine or bone voids.
• KINEX^® PLUS Gel: Extrudable formula packaged in a luer lock syringe for controlled delivery.

1 Xynos ID, Edgar AJ, Buttery LDK, Hench LL, Polak JM. Ionic products of bioactive glass dissolution increase proliferation of human osteoblasts and induce insulin-like growth factor II mRNA expression and protein synthesis. Biochem. Biophys. Res. Commun. 2000; 276: 461–465.
2 Xynos ID, Hukkanen MV, Batten JJ, Buttery LD, Hench LL, Polak JM, Bioglass 45S5 Stimulates Osteoblast Turnover and Enhances Bone Formation In Vitro: Implications and Applications for Bone Tissue Engineering. Calcif. Tissue Int. 2000; 67: 321–329.
3 Ducheyne P, Qiu Q: Bioactive ceramics: the effect of surface reactivity on bone formation and bone cell function. Biomaterials 1999; 20: 2287–2303.
4 Sasaki T, Watanabe C. Stimulation of osteoinduction in bone wound healing by high-molecular weight hyaluronic acid. Bone 1995; 16: 9–15.
5 West DC, Hampson IN, Arnold F, Kumar S. Angiogenesis induced by degradation products of hyaluronic acid. Science 1985; 14:1324–1326.
6 Morin R, Kaplan D, Perez-Ramirez B. Bone morphogenetic protein-2 binds as multilayers to a collagen delivery matrix: an equilibrium thermodynamic analysis. Biomacromolecules 2006; 7(1): 131–8.
7 Geiger M, Li, RH, Friess W. Collagen sponges for bone regeneration with rhBMP-2. Adv Drug Deliv Rev. 2003, 55: 1613–1629.